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Lengyel, Ernst Robert
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overview I trained both as a scientist and as a physician and, throughout my career, I have focused on the treatment and biology of ovarian cancer (OvCa). My Ph.D. thesis was on the role of proteases in ovarian cancer and my clinical fellowship involved a special emphasis on the treatment of patients with this disease. As a surgeon and clinician, I am familiar with the presentation of ovarian cancer in patients, and experience the incredible obstacles we face in its treatment. In the laboratory, I have built the research infrastructure necessary for effective ovarian cancer research. The Lengyel lab has elucidated, at least in part, the first critical steps of ovarian cancer metastasis by paying close attention to the host microenvironment. We have collected the 25 most commonly used ovarian cancer cell lines from all over the world, including those which are chemotherapy resistant. We have established several mouse models for OvCa, and using a genetic mouse model (K-rasG12D/+/Pten-/- -- established by Dr. Tyler Jacks), a syngeneic orthotopic mouse model using mouse OvCa cells (ID8 -- established by K. Roby), and several xenograft ip models using primary and cultured human OvCa cells. I have also established a prospective OvCa tissue bank and, together with 2 gynecologic pathologists, we have assembled 13 tissue arrays including normal tissue, borderline tumor and primary tumor, & corresponding metastasis. As a surgeon, the main focus of my practice is patients with OvCa; therefore, I will be able to enroll a substantial number of patients on the proposed clinical trial and have the infrastructure in place to collect the tissue required for the translational studies. My clinical experience treating ovarian cancer, together with my laboratory, which focuses on OvCa biology, gives me a unique opportunity and obligation to find new treatments that can benefit patients with ovarian cancer.
Person ID 1942
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Concept Adenosine
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Academic Article Regulation of urokinase-type plasminogen activator expression by an ERK1-dependent signaling pathway in a squamous cell carcinoma cell line.
Academic Article Requirement of an upstream AP-1 motif for the constitutive and phorbol ester-inducible expression of the urokinase-type plasminogen activator receptor gene.
Academic Article In vitro modulation of human melanoma cell invasion and proliferation by all-trans-retinoic acid.
Academic Article Elevated keratin 18 protein expression indicates a favorable prognosis in patients with breast cancer.
Academic Article Activation mechanisms of the urokinase-type plasminogen activator promoter by hepatocyte growth factor/scatter factor.
Academic Article Elevated urokinase-type plasminogen activator receptor expression in a colon cancer cell line is due to a constitutively activated extracellular signal-regulated kinase-1-dependent signaling cascade.
Academic Article Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades.
Academic Article [The clinical importance of keratin 18 in breast cancer].
Academic Article beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter.
Academic Article Integrin alpha(v)beta(3)/vitronectin interaction affects expression of the urokinase system in human ovarian cancer cells.
Academic Article Gastrin induces expression and promoter activity of the vesicular monoamine transporter subtype 2.
Academic Article UVB increases urokinase-type plasminogen activator receptor (uPAR) expression.
Academic Article JNK and p38MAPK are activated during graft reperfusion and not during cold storage in rat liver transplantation.
Academic Article Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b.
Academic Article Downregulation of a mitogen-activated protein kinase signaling pathway in the placentas of women with preeclampsia.
Academic Article Increased expression of matrix metalloproteinases (MMP)-2, MMP-9, and the urokinase-type plasminogen activator is associated with progression from benign to advanced ovarian cancer.
Academic Article Tumor-specific transcription factor binding to an activator protein-2/Sp1 element of the urokinase-type plasminogen activator receptor promoter in a first large series of resected gastrointestinal cancers.
Academic Article Role of beta(3)-endonexin in the regulation of NF-kappaB-dependent expression of urokinase-type plasminogen activator receptor.
Academic Article Ras regulation of urokinase-type plasminogen activator.
Academic Article Expression of latent matrix metalloproteinase 9 (MMP-9) predicts survival in advanced ovarian cancer.
Academic Article Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation.
Academic Article Isolation and characterization of Rac1 pseudogenes (psi1Rac1-psi4Rac1) in the human genome.
Academic Article Dosimetric predictors of acute hematologic toxicity in cervical cancer patients treated with concurrent cisplatin and intensity-modulated pelvic radiotherapy.
Academic Article PDGFR-alpha as a potential therapeutic target in uterine sarcomas.
Academic Article Single-agent pulse dactinomycin has only modest activity for methotrexate-resistant gestational trophoblastic neoplasia.
Academic Article Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2.
Academic Article C-Met overexpression in node-positive breast cancer identifies patients with poor clinical outcome independent of Her2/neu.
Academic Article Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer.
Academic Article Does equal treatment yield equal outcomes? The impact of race on survival in epithelial ovarian cancer.
Academic Article Reversible posterior leukoencephalopathy syndrome following intravenous paclitaxel and intraperitoneal cisplatin chemotherapy for fallopian tube cancer.
Academic Article Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface.
Academic Article The initial steps of ovarian cancer cell metastasis are mediated by MMP-2 cleavage of vitronectin and fibronectin.
Academic Article An orally available small-molecule inhibitor of c-Met, PF-2341066, reduces tumor burden and metastasis in a preclinical model of ovarian cancer metastasis.
Academic Article MMP-2 functions as an early response protein in ovarian cancer metastasis.
Academic Article Combination analysis of activator protein-1 family members, Sp1 and an activator protein-2alpha-related factor binding to different regions of the urokinase receptor gene in resected colorectal cancers.
Academic Article Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice.
Academic Article c-Met overexpression is a prognostic factor in ovarian cancer and an effective target for inhibition of peritoneal dissemination and invasion.
Academic Article A phase II, single-arm study of the anti-a5ß1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer.
Academic Article Let-7 expression defines two differentiation stages of cancer.
Academic Article Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1.
Academic Article Loss of E-cadherin promotes ovarian cancer metastasis via alpha 5-integrin, which is a therapeutic target.
Academic Article Ligand-independent activation of c-Met by fibronectin and a(5)ß(1)-integrin regulates ovarian cancer invasion and metastasis.
Academic Article Foretinib (GSK1363089), an orally available multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces anoikis, and impairs ovarian cancer metastasis.
Academic Article The Müllerian HOXA10 gene promotes growth of ovarian surface epithelial cells by stimulating epithelial-stromal interactions.
Academic Article FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas.
Academic Article A special key for unlocking the door to targeted therapies of breast cancer.
Academic Article The effects of 17ß-estradiol and a selective estrogen receptor modulator, bazedoxifene, on ovarian carcinogenesis.
Academic Article Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Academic Article {beta}3-integrin expression on tumor cells inhibits tumor progression, reduces metastasis, and is associated with a favorable prognosis in patients with ovarian cancer.
Academic Article Targeting the urokinase plasminogen activator receptor inhibits ovarian cancer metastasis.
Academic Article Acute inflammatory reaction following placement of sodium hyaluronate-carboxymethylcellulose barrier in a young woman undergoing gynecologic surgery: a case report.
Academic Article Rethinking ovarian cancer: recommendations for improving outcomes.
Academic Article Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure.
Academic Article Involvement of a mitogen-activated protein kinase signaling pathway in the regulation of urokinase promoter activity by c-Ha-ras.
Academic Article The first line of intra-abdominal metastatic attack: breaching the mesothelial cell layer.
Academic Article Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene.
Academic Article Tyrosine kinase mutations in human cancer.
Academic Article Use of a novel 3D culture model to elucidate the role of mesothelial cells, fibroblasts and extra-cellular matrices on adhesion and invasion of ovarian cancer cells to the omentum.
Academic Article Keratin expression reveals mosaic differentiation in vaginal epithelium.
Academic Article The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2.
Academic Article Stimulation of urokinase expression by TNF-alpha requires the activation of binding sites for the AP-1 and PEA3 transcription factors.
Academic Article Induction of M(r) 92,000 type IV collagenase expression in a squamous cell carcinoma cell line by fibroblasts.
Academic Article The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.
Academic Article Ovarian cancer development and metastasis.
Academic Article Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase 1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences.
Academic Article The expression of hepatocyte growth factor (HGF) and c-Met in uterine serous carcinoma.
Academic Article HOXA9 promotes ovarian cancer growth by stimulating cancer-associated fibroblasts.
Academic Article Transient interaction of activated platelets with endothelial cells induces expression of monocyte-chemoattractant protein-1 via a p38 mitogen-activated protein kinase mediated pathway. Implications for atherogenesis.
Academic Article Differential expression of c-Met, its ligand HGF/SF and HER2/neu in DCIS and adjacent normal breast tissue.
Academic Article A novel multipurpose monoclonal antibody for evaluating human c-Met expression in preclinical and clinical settings.
Academic Article Up-regulation of alpha5-integrin by E-cadherin loss in hypoxia and its key role in the migration of extravillous trophoblast cells during early implantation.
Academic Article Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation.
Academic Article Organotypic models of metastasis: A three-dimensional culture mimicking the human peritoneum and omentum for the study of the early steps of ovarian cancer metastasis.
Academic Article Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity.
Academic Article Angiography-proven liver metastases explain low efficacy of lymph node dissections in medullary thyroid cancer patients.
Academic Article miR-92a inhibits peritoneal dissemination of ovarian cancer cells by inhibiting integrin a5 expression.
Academic Article Serial sectioning of the fallopian tube allows for improved identification of primary fallopian tube carcinoma.
Academic Article MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer.
Academic Article Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion.
Academic Article Expression of the homeobox gene HOXA9 in ovarian cancer induces peritoneal macrophages to acquire an M2 tumor-promoting phenotype.
Academic Article Adipose tissue and adipocytes support tumorigenesis and metastasis.
Academic Article Utility of routine surveillance methods in detecting recurrence in high grade endometrial cancer patients.
Academic Article Three-dimensional modeling of ovarian cancer.
Academic Article Urokinase plasminogen activator system-targeted delivery of nanobins as a novel ovarian cancer therapy.
Academic Article Epithelial ovarian cancer experimental models.
Academic Article Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting.
Academic Article Old drug, new trick: repurposing metformin for gynecologic cancers?
Academic Article Molecular pathways: trafficking of metabolic resources in the tumor microenvironment.
Academic Article [Juvenile aneuploid papillary cancer of the thyroid with pulmonary metastasis].
Academic Article Patterns and utility of routine surveillance in high grade endometrial cancer.
Academic Article The hypoxia-related microRNA miR-199a-3p displays tumor suppressor functions in ovarian carcinoma.
Academic Article Glucocorticoid receptor activation inhibits chemotherapy-induced cell death in high-grade serous ovarian carcinoma.
Academic Article Hyperglycemia-induced metabolic compensation inhibits metformin sensitivity in ovarian cancer.
Academic Article Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer.
Academic Article Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.
Academic Article Corrigendum: Whole-genome characterization of chemoresistant ovarian cancer.
Academic Article Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity.
Academic Article Erratum: Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
Academic Article A prospective study evaluating diffusion weighted magnetic resonance imaging (DW-MRI) in the detection of peritoneal carcinomatosis in suspected gynecologic malignancies.
Academic Article Integrative proteomic profiling of ovarian cancer cell lines reveals precursor cell associated proteins and functional status.
Academic Article Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers.
Academic Article Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells.
Academic Article Reversal of Chemoresistance in Ovarian Cancer by Co-Delivery of a P-Glycoprotein Inhibitor and Paclitaxel in a Liposomal Platform.
Academic Article Genomics of Ovarian Cancer Progression Reveals Diverse Metastatic Trajectories Including Intraepithelial Metastasis to the Fallopian Tube.
Academic Article Ovarian cancer treatment in black and white women: A comparison of clinico-pathologic factors and outcome.
Academic Article Gastrin Induces Expression and Promoter Activity of the Vesicular Monoamine Transporter Subtype 2.
Academic Article Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.
Academic Article Loss of BRCA1 in the Cells of Origin of Ovarian Cancer Induces Glycolysis: A Window of Opportunity for Ovarian Cancer Chemoprevention.
Academic Article High glucocorticoid receptor expression predicts short progression-free survival in ovarian cancer.
Academic Article Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer.
Academic Article Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor-Engineered T Cells for Ovarian Cancer.
Academic Article A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns.
Academic Article An activity-dependent proximity ligation platform for spatially resolved quantification of active enzymes in single cells.
Academic Article Who are the long-term survivors of high grade serous ovarian cancer?
Academic Article Adipocyte-induced CD36 expression drives ovarian cancer progression and metastasis.
Academic Article m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article The road to long-term survival: Surgical approach and longitudinal treatments of long-term survivors of advanced-stage serous ovarian cancer.
Academic Article Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis.
Academic Article Pressure tuning of the interplay of magnetism and superconductivity in CeCu2Si2.
Academic Article Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum.
Academic Article SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
Academic Article Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference.
Academic Article Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.
Academic Article Quantitative High-Throughput Screening Using an Organotypic Model Identifies Compounds that Inhibit Ovarian Cancer Metastasis.
Academic Article Ultrasensitive, multiplexed chemoproteomic profiling with soluble activity-dependent proximity ligation.
Academic Article Mesothelial Cell HIF1a Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk.
Academic Article RADAR: differential analysis of MeRIP-seq data with a random effect model.
Academic Article Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake.
Academic Article Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance.
Academic Article A streamlined mass spectrometry-based proteomics workflow for large-scale FFPE tissue analysis.
Academic Article Care of Transgender Persons.
Academic Article Healthy food for trainees: a call to action.
Academic Article Deconstructing tumor heterogeneity: the stromal perspective.
Academic Article Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment.
Academic Article Change in Health-Related Socioeconomic Risk Factors and Mental Health During the Early Phase of the COVID-19 Pandemic: A National Survey of U.S. Women.
Academic Article Twenty-year longitudinal study on aged people in Budapest.
Academic Article Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis.
Academic Article The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer.
Academic Article The Effects of Chemotherapeutics on the Ovarian Cancer Microenvironment.
Academic Article The Natural Product ß-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.
Academic Article Germline mutations in Black patients with ovarian, fallopian tube and primary peritoneal carcinomas.
Academic Article Resilience: a mediator of the negative effects of pandemic-related stress on women's mental health in the USA.
Academic Article Neoadjuvant Chemotherapy Induces Genomic and Transcriptomic Changes in Ovarian Cancer.
Academic Article Resilience in the Face of Pandemic: The Impact of COVID-19 on the Psychologic Morbidity and Health-Related Quality of Life Among Women With Ovarian Cancer.
Academic Article High glucocorticoid receptor expression in the sarcomatous versus carcinomatous elements of Mullerian carcinosarcomas.
Academic Article Deep Visual Proteomics defines single-cell identity and heterogeneity.
Academic Article Physiological age-related changes: cross-sectional and longitudinal studies.
Academic Article Molecular Characterizations of Gynecologic Carcinosarcomas: A Focus on the Immune Microenvironment.
Academic Article A molecular atlas of the human postmenopausal fallopian tube and ovary from single-cell RNA and ATAC sequencing.
Concept Poly(ADP-ribose) Polymerase Inhibitors
Concept Bevacizumab
Concept Protein Domains
Concept Circulating MicroRNA
Concept Cancer-Associated Fibroblasts
Concept Liquid Biopsy
Concept MCF-7 Cells
Concept Clustered Regularly Interspaced Short Palindromic Repeats
Concept Cytoreduction Surgical Procedures
Concept Datasets as Topic
Academic Article Understanding Long-Term Survival of Patients with Ovarian Cancer-The Tumor Microenvironment Comes to the Forefront.
Academic Article The glycoprotein CD147 defines miRNA-enriched extracellular vesicles that derive from cancer cells.
Academic Article Decoding evolutionary trajectories of ovarian cancer metastasis.
Academic Article Normal saline remodels the omentum and stimulates its receptivity for transcoelomic metastasis.
Academic Article Adipocytes reprogram cancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promoting metastasis.
Academic Article Spatial proteo-transcriptomic profiling reveals the molecular landscape of borderline ovarian tumors and their invasive progression.
Academic Article 5-Hydroxymethylcytosine signals in serum are a predictor of chemoresistance in high-grade serous ovarian cancer.
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